Design, synthesis and anti-microbial activity of 1H-pyrazole carboxylates

Radhakrishnan Sridhar; Paramasivam T Perumal; Sundaresan Etti; Guruswamy Shanmugam; Mondikalipudur N Ponnuswamy; Vaiyapuri R Prabavathy; Narayanasamy Mathivanan

doi:10.1016/j.bmcl.2004.09.066

Design, synthesis and anti-microbial activity of 1H-pyrazole carboxylates

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6035-40. doi: 10.1016/j.bmcl.2004.09.066.

Authors

Radhakrishnan Sridhar¹, Paramasivam T Perumal, Sundaresan Etti, Guruswamy Shanmugam, Mondikalipudur N Ponnuswamy, Vaiyapuri R Prabavathy, Narayanasamy Mathivanan

Affiliation

¹ Organic Chemistry Division, Central Leather Research Institute, Chennai 600 020, India.

PMID: 15546724
DOI: 10.1016/j.bmcl.2004.09.066

Abstract

In a SAR study, we have synthesized a few 1H-pyrazole carboxylate related microbicides using Vilsmeier reagent. The anti-microbial screening results of 1H-pyrazole-3-carboxylate are reported here for the first time. The effect of 1H-pyrazole carboxylates on the mycelial growth of plant pathogenic fungi is revealed. The first X-ray structure in the family of microbicidal 1H-pyrazole-4-carboxylates is presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents* / chemical synthesis
Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / pharmacology
Antifungal Agents* / chemical synthesis
Antifungal Agents* / chemistry
Antifungal Agents* / pharmacology
Carboxylic Acids* / chemical synthesis
Carboxylic Acids* / chemistry
Carboxylic Acids* / pharmacology
Drug Design*
Humans
Microbial Sensitivity Tests
Models, Chemical
Molecular Structure
Pyrazoles* / chemical synthesis
Pyrazoles* / chemistry
Pyrazoles* / pharmacology
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Antifungal Agents
Carboxylic Acids
Pyrazoles