DNA replication: stalling a fork for imprinting and switching

Curr Biol. 2004 Nov 9;14(21):R915-7. doi: 10.1016/j.cub.2004.10.012.

Abstract

Mating-type switching in fission yeast has long been known to be directed by a DNA 'imprint'. This imprint has now been firmly characterized as a protected site-specific and strand-specific nick. New work also links the widely conserved Swi1-Swi3 complex to the protection of stalled replication forks in general.

Publication types

  • Review
  • Comment

MeSH terms

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DNA Replication / physiology*
  • DNA-Binding Proteins
  • Genes, Fungal / genetics*
  • Genes, Mating Type, Fungal*
  • Models, Genetic*
  • Nuclear Proteins / genetics
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins / genetics
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces pombe Proteins
  • Trans-Activators / genetics
  • Transcription Factors / genetics

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Nuclear Proteins
  • SWI1 protein, S cerevisiae
  • SWI3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • Trans-Activators
  • Transcription Factors
  • swi1 protein, S pombe