SRP meets the ribosome

Nat Struct Mol Biol. 2004 Nov;11(11):1049-53. doi: 10.1038/nsmb853.

Abstract

Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Crystallography, X-Ray
  • Guanosine Triphosphate / chemistry
  • Humans
  • Models, Biological
  • Protein Biosynthesis
  • Protein Conformation
  • Protein Structure, Tertiary
  • Protein Transport
  • Ribosomes / metabolism
  • Ribosomes / physiology*
  • Saccharomyces cerevisiae Proteins / physiology
  • Signal Recognition Particle* / physiology
  • Signal Transduction
  • Sulfolobus / physiology

Substances

  • SRP54 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Signal Recognition Particle
  • Guanosine Triphosphate