[Liver regeneration after resection: molecular and cellular mechanism]

Go Wakabayashi; Motohide Shimazu; Masakazu Ueda; Minoru Tanabe; Shigeyuki Kawachi; Masaki Kitajima

[Liver regeneration after resection: molecular and cellular mechanism]

Nihon Geka Gakkai Zasshi. 2004 Oct;105(10):650-3.

[Article in Japanese]

Authors

Go Wakabayashi¹, Motohide Shimazu, Masakazu Ueda, Minoru Tanabe, Shigeyuki Kawachi, Masaki Kitajima

Affiliation

¹ Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

PMID: 15521380

Abstract

It has been well established that the liver can regenerate after resection. Liver regeneration is a fundamental mechanism by which the liver responds to injury. This review article discusses molecular and cellular mechanism of liver regeneration, including growth factors and cytokines in the initiation and regulation of liver regeneration, the importance of the liver extracellular matrix and its dynamic effect on hepatocyte growth, and finally, stem cell biology in liver regeneration.

Publication types

Review

MeSH terms

Animals
Cell Cycle / genetics
DNA / biosynthesis
DNA-Binding Proteins / physiology
Extracellular Matrix / metabolism
Hepatectomy*
Hepatocyte Growth Factor / physiology
Hepatocytes / cytology*
Hepatocytes / metabolism
Humans
Interleukin-6 / physiology
Liver Regeneration / genetics*
Liver Regeneration / physiology
NF-kappaB-Inducing Kinase
Protein Serine-Threonine Kinases / physiology
STAT3 Transcription Factor
Stem Cells / cytology
Trans-Activators / physiology
Tumor Necrosis Factor-alpha / physiology
Urokinase-Type Plasminogen Activator / physiology

Substances

DNA-Binding Proteins
Interleukin-6
STAT3 Transcription Factor
STAT3 protein, human
Trans-Activators
Tumor Necrosis Factor-alpha
Hepatocyte Growth Factor
DNA
Protein Serine-Threonine Kinases
Urokinase-Type Plasminogen Activator