Abstract
Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Butyrylcholinesterase / metabolism
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification
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Cholinesterase Inhibitors / pharmacology*
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Lignans / chemistry
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Lignans / isolation & purification
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Lignans / pharmacology*
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Lipoxygenase / metabolism
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Lipoxygenase Inhibitors / chemistry
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Lipoxygenase Inhibitors / isolation & purification
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Lipoxygenase Inhibitors / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Roots
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Vitex*
Substances
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Cholinesterase Inhibitors
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Lignans
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Lipoxygenase Inhibitors
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Plant Extracts
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Lipoxygenase
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Butyrylcholinesterase