Abstract
The new palladium (II) and platinum (II) complexes 2 and 3 with 3-ethanimidoyl-2-methoxy-2H-1,2-benzoxaphospinin-4-ol-2-oxide 1 were synthesized and their physicochemical and pharmacological properties were determined. The cytotoxic effects of these complexes were examined on the two human leukemia cell lines, HL-60 and NALM-6. Pd-complex 2 and Pt-complex 3 exerted significant cytotoxic activity. The effects exhibited by these two complexes were comparable to those reported for cis-platin and carboplatin. On the other hand, ligand 1 was not cytotoxic. As determined by caspase-3 activity assay, compounds 2 and 3 differed slightly in their mode of induction of the programmed cell death.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects*
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Caspase 3
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Caspases / metabolism
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Enzyme Induction
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Humans
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Imides / chemistry
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Imides / pharmacology*
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Molecular Structure
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Organophosphorus Compounds / chemistry
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Organophosphorus Compounds / pharmacology*
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology
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Palladium*
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Platinum*
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Time Factors
Substances
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3-ethanimidoyl-2-methoxy-2H-1,2-benzoxaphospinin-4-ol-2-oxide
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Antineoplastic Agents
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Imides
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Organometallic Compounds
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Organophosphorus Compounds
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Organoplatinum Compounds
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Platinum
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Palladium
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CASP3 protein, human
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Caspase 3
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Caspases