[The role of HMG-CoA reductase inhibitors in regulation of the inflammatory processes]

Wiad Lek. 2004;57(5-6):255-8.
[Article in Polish]

Abstract

Statins operate through inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a key enzyme which regulates intracellular cholesterol synthesis. Their so-called pleiotropic effects incorporate alterations of endothelial function, inflammation, coagulation and plaque stability. This review will focus on statins regulation role in inflammation.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Cholesterol / biosynthesis
  • Cholesterol / metabolism
  • Coronary Artery Disease / drug therapy*
  • Coronary Artery Disease / metabolism
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / metabolism
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Inflammation / drug therapy*
  • Inflammation / metabolism
  • Nitric Oxide Synthase / biosynthesis
  • Oxidative Stress / drug effects

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Cholesterol
  • Nitric Oxide Synthase