Abstract
Statins operate through inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a key enzyme which regulates intracellular cholesterol synthesis. Their so-called pleiotropic effects incorporate alterations of endothelial function, inflammation, coagulation and plaque stability. This review will focus on statins regulation role in inflammation.
MeSH terms
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Cholesterol / biosynthesis
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Cholesterol / metabolism
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Coronary Artery Disease / drug therapy*
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Coronary Artery Disease / metabolism
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Endothelium, Vascular / drug effects*
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Endothelium, Vascular / metabolism
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Inflammation / drug therapy*
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Inflammation / metabolism
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Nitric Oxide Synthase / biosynthesis
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Oxidative Stress / drug effects
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Cholesterol
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Nitric Oxide Synthase