Abstract
Administration of B. diffusa leaf extract (BLEt; 200 mg/kg) for 4 weeks resulted in a significant reduction in thiobarbutric acid reactive substances and hydroperoxides, with a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione--S-transferase in liver and kidney of alloxan induced diabetic rats. The results suggest that BLEt has remarkable antidiabetic activity and can improve antioxidant status in alloxan induced diabetic rats.
MeSH terms
-
Animals
-
Antioxidants / metabolism
-
Antioxidants / pharmacology*
-
Diabetes Mellitus, Experimental / drug therapy*
-
Diabetes Mellitus, Experimental / metabolism*
-
Glutathione / metabolism
-
Hypoglycemic Agents / pharmacology
-
Lipid Peroxidation / drug effects
-
Liver / metabolism
-
Nyctaginaceae*
-
Phytotherapy*
-
Plant Extracts / pharmacology
-
Rats
-
Thiobarbituric Acid Reactive Substances / metabolism
Substances
-
Antioxidants
-
Hypoglycemic Agents
-
Plant Extracts
-
Thiobarbituric Acid Reactive Substances
-
Glutathione