Abstract
Several thiazolyl/benzothiazolyl/benzo[d]isothiazolyl Schiff bases and hydrazones have been tested as anti-inflammatory agents and five new compounds have been synthesized. The anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema test (inhibition 16.3-64%). The compounds were tested for antioxidant activity as hydroxyl scavengers and for their ability to interact with the stable free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH). Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology*
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Biphenyl Compounds
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Carrageenan
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Chemical Phenomena
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Chemistry, Physical
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Dimethyl Sulfoxide / chemistry
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Edema / chemically induced
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Edema / prevention & control
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Female
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / pharmacology
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Hydroxyl Radical / chemistry
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Mice, Inbred AKR
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Picrates / chemistry
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Pregnancy
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Quantitative Structure-Activity Relationship
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Schiff Bases
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Spectrophotometry, Infrared
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology*
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Thiosemicarbazones / chemical synthesis*
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Thiosemicarbazones / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antioxidants
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Biphenyl Compounds
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Free Radical Scavengers
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Indicators and Reagents
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Picrates
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Schiff Bases
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Thiazoles
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Thiosemicarbazones
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Hydroxyl Radical
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Carrageenan
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1,1-diphenyl-2-picrylhydrazyl
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Dimethyl Sulfoxide