Protective effect of phenyl-t-butylnitrone in rats with focal cerebral ischemia

Bull Exp Biol Med. 2003 Dec;136(6):560-2. doi: 10.1023/b:bebm.0000020203.94421.d5.

Abstract

Phenyl-t-butylnitrone produces a potent neuroprotective effect in rats with focal cerebral ischemia modeled by distal occlusion of the middle cerebral artery. The infarction area markedly decreased after treatment with phenyl-t-butylnitrone. The content of phenyl-t-butylnitrone in the brain, liver, and kidneys was measured by the method of electron paramagnetic resonance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Chemistry / drug effects
  • Brain Ischemia / etiology
  • Brain Ischemia / pathology
  • Brain Ischemia / prevention & control*
  • Cyclic N-Oxides
  • Disease Models, Animal
  • Electron Spin Resonance Spectroscopy
  • Free Radicals
  • Infarction, Middle Cerebral Artery / complications
  • Kidney / chemistry
  • Kidney / drug effects
  • Liver / chemistry
  • Liver / drug effects
  • Male
  • Neuroprotective Agents / analysis
  • Neuroprotective Agents / pharmacology*
  • Nitrogen Oxides / analysis
  • Nitrogen Oxides / pharmacology*
  • Rats
  • Rats, Wistar
  • Spin Labels

Substances

  • Cyclic N-Oxides
  • Free Radicals
  • Neuroprotective Agents
  • Nitrogen Oxides
  • Spin Labels
  • phenyl-N-tert-butylnitrone