Abstract
Phenyl-t-butylnitrone produces a potent neuroprotective effect in rats with focal cerebral ischemia modeled by distal occlusion of the middle cerebral artery. The infarction area markedly decreased after treatment with phenyl-t-butylnitrone. The content of phenyl-t-butylnitrone in the brain, liver, and kidneys was measured by the method of electron paramagnetic resonance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Chemistry / drug effects
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Brain Ischemia / etiology
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Brain Ischemia / pathology
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Brain Ischemia / prevention & control*
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Cyclic N-Oxides
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Disease Models, Animal
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Electron Spin Resonance Spectroscopy
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Free Radicals
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Infarction, Middle Cerebral Artery / complications
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Kidney / chemistry
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Kidney / drug effects
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Liver / chemistry
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Liver / drug effects
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Male
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Neuroprotective Agents / analysis
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Neuroprotective Agents / pharmacology*
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Nitrogen Oxides / analysis
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Nitrogen Oxides / pharmacology*
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Rats
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Rats, Wistar
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Spin Labels
Substances
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Cyclic N-Oxides
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Free Radicals
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Neuroprotective Agents
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Nitrogen Oxides
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Spin Labels
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phenyl-N-tert-butylnitrone