Tetradehydrohalicyclamine A and 22-hydroxyhalicyclamine A, new cytotoxic bis-piperidine alkaloids from a marine sponge Amphimedon sp

J Nat Prod. 2004 Oct;67(10):1758-60. doi: 10.1021/np049824a.

Abstract

Two new 3-alkylpiperidine alkaloids, tetradehydrohalicyclamine A (2) and 22-hydroxyhalicyclamine A (3), have been isolated from a marine sponge Amphimedon sp. as cytotoxic constituents. Their structures were elucidated by spectroscopic analysis. Compounds 2 and 3 inhibited growth of P388 cells with IC50 values of 2.2 and 0.45 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Inhibitory Concentration 50
  • Japan
  • Leukemia P388
  • Mice
  • Mice, Inbred DBA
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Piperidines / chemistry
  • Piperidines / isolation & purification*
  • Piperidines / pharmacology
  • Porifera / chemistry*
  • Tumor Cells, Cultured

Substances

  • 22-hydroxyhalicyclamine A
  • Alkaloids
  • Antineoplastic Agents
  • Piperidines
  • tetradehydrohalicyclamine A