Abstract
Two new 3-alkylpiperidine alkaloids, tetradehydrohalicyclamine A (2) and 22-hydroxyhalicyclamine A (3), have been isolated from a marine sponge Amphimedon sp. as cytotoxic constituents. Their structures were elucidated by spectroscopic analysis. Compounds 2 and 3 inhibited growth of P388 cells with IC50 values of 2.2 and 0.45 microg/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Inhibitory Concentration 50
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Japan
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Leukemia P388
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Mice
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Mice, Inbred DBA
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Piperidines / chemistry
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Piperidines / isolation & purification*
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Piperidines / pharmacology
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Porifera / chemistry*
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Tumor Cells, Cultured
Substances
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22-hydroxyhalicyclamine A
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Alkaloids
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Antineoplastic Agents
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Piperidines
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tetradehydrohalicyclamine A