New sesterterpenes from the sponge Smenospongia sp

J Nat Prod. 2004 Oct;67(10):1748-51. doi: 10.1021/np040103l.

Abstract

Five new sesterterpenes, three scalarane-type (1-3) and two linear furanosesterterpenes (4, 5), were isolated from the marine sponge Smenospongia sp. collected from Gagu-Do, Korea. The structures of the new compounds, which exhibited moderate cytotoxicity toward the human leukemia cell line K562, were determined from an analysis of spectroscopic data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • K562 Cells
  • Korea
  • Molecular Structure
  • Porifera / chemistry*
  • Sesterterpenes
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology

Substances

  • Antineoplastic Agents
  • Sesterterpenes
  • Terpenes