Abstract
Nine monotetrahydrofuranic Annonaceous acetogenins, montalicins A-E (1-5), cis-annoreticuin (6), montalicins F (7), I (8), and J (9), along with eight known acetogenins 10-17, were isolated from the seeds of Annona montana by a high performance liquid chromatographic (HPLC) method. The structures of all new isolates were elucidated and characterized by spectroscopic and chemical methods. These monotetrahydrofuranic Annonaceous acetogenins showed selectively potent cytotoxicity against two human cancer cell lines, 1A9 and Hep G2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetogenins
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Annona*
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Cell Line, Tumor / drug effects
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Fatty Alcohols / administration & dosage
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Fatty Alcohols / chemistry
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Fatty Alcohols / pharmacology
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Fatty Alcohols / therapeutic use
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Furans / administration & dosage
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Furans / chemistry
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Furans / pharmacology
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Furans / therapeutic use
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Humans
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Lactones / administration & dosage
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Lactones / chemistry
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Lactones / pharmacology
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Lactones / therapeutic use
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Seeds
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Structure-Activity Relationship
Substances
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Acetogenins
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Antineoplastic Agents, Phytogenic
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Fatty Alcohols
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Furans
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Lactones
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Plant Extracts