Objective: To assess plasma renin activity in a patient with severe ovarian hyperstimulation syndrome (OHSS) and internal jugular vein thrombosis.
Design: Case report.
Setting: University-affiliated infertility center.
Patient(s): A 33-year-old woman with OHSS and internal jugular vein thrombosis.
Intervention(s): Controlled ovulation hyperstimulation with recombinant FSH induction.
Main outcome measure(s): Plasma renin activity (PRA), color Doppler ultrasound of the neck.
Result(s): The patient had internal jugular vein thrombosis caused by severe OHSS. The PRA was significantly elevated during the acute stage and subsequently declined after resolution of the OHSS.
Conclusion(s): In this patient elevated PRA appeared to be associated with the development of OHSS and thrombosis. The implication of the ovarian renin-angiotensin system in the development of OHSS and thrombosis is relevant.