The purpose of this article is to serve as a resource for readers considering the development of a web-based continuing education offering in their particular specialty areas. A theory-based instructional design using a face-to-face genetics summer institute as a content template and incorporating several levels of planned formative evaluation are described. Summative evaluation strategies revealing satisfaction with the format, improved knowledge, and ability to use genetics knowledge in participants' work setting are also discussed. Finally, lessons learned following completion of two 18-week web-based genetics institutes are shared.