Abstract
Introduction:
Although ocular involvement concerns about 25 to 60% of patients with systemic sarcoidosis, papilledema is a rare event.
Exegesis:
A 43-year-old man presented with left visual loss related to papillitis. Despite high-dose corticosteroids, visual loss became rapidly bilateral. Thoracic CT-scan showed mediastinal and parenchymal involvement. Histological study of lung, bronchial and lymphadenopathy biopsies displayed giant-cells granuloma without necrosis. Diagnosis of sarcoidosis complicated with optic neuropathy was made. Therapy combining prednisone, methotrexate and infliximab was started without significant improvement of visual acuity.
Conclusion:
This report underlines the potential severity of optic neuropathy in sarcoidosis.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / therapeutic use
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / therapeutic use
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Blindness / etiology*
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Diabetes Mellitus, Type 1 / complications
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Drug Therapy, Combination
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Follow-Up Studies
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Humans
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / therapeutic use
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Infliximab
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Male
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Methotrexate / administration & dosage
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Methotrexate / therapeutic use
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Optic Atrophy / diagnosis
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Optic Atrophy / etiology
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Optic Nerve Diseases / diagnosis
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Optic Nerve Diseases / etiology*
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Prednisone / administration & dosage
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Prednisone / therapeutic use
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Sarcoidosis / complications*
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Sarcoidosis / diagnosis
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Sarcoidosis / drug therapy
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Time Factors
Substances
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Anti-Inflammatory Agents
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Antibodies, Monoclonal
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Immunosuppressive Agents
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Infliximab
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Prednisone
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Methotrexate