Molecular genetics of hereditary hair and nail disease

M A M van Steensel; M van Geel; P M Steijlen

doi:10.1002/ajmg.c.30034

Molecular genetics of hereditary hair and nail disease

Am J Med Genet C Semin Med Genet. 2004 Nov 15;131C(1):52-60. doi: 10.1002/ajmg.c.30034.

Authors

M A M van Steensel¹, M van Geel, P M Steijlen

Affiliation

¹ Dermatology Department, University Hospital Maastricht, the Netherlands. mvst@sder.azm.nl

PMID: 15468149
DOI: 10.1002/ajmg.c.30034

Abstract

Hair and nail development have many similarities and are likely to share many developmental pathways. This is evident from the ectodermal dysplasias that affect both appendages. Of special interest are syndromic disorders as they show the effects of disturbances in molecular pathways that are essential for normal embryonic development. In this review, recent results from studies of syndrome affecting hair and nail development will be discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Adhesion / physiology
Cytoskeleton / physiology
Desmosomes / physiology
Gene Expression Regulation
Hair Diseases / genetics*
Hair Diseases / pathology*
Hair Follicle / embryology
Hair Follicle / physiopathology
Humans
Nail Diseases / genetics*
Nail Diseases / pathology*
Nails / embryology
Nails / physiopathology
Syndrome