Abstract
Phytochemical investigation of the rhizome of Dioscorea opposita has led to the isolation of a new phenanthrene glycoside, 3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside (1), and five known compounds, soyacerebroside I (2), adenosine (3), beta-sitosterol (4), palmitic acid (5) and palmitoyloleoylphosphatidylcholine (6). Their structures were determined by spectroscopic methods, including 1D- and 2D-NMR. Compounds 1-6 exhibited no antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis.
MeSH terms
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Candida / drug effects
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Dioscorea*
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
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Phenanthrenes / chemistry*
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Phenanthrenes / isolation & purification
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Phenanthrenes / pharmacology
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Plant Extracts
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Rhizome
Substances
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3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside
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Antifungal Agents
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Glycosides
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Phenanthrenes
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Plant Extracts