Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study

Parkinsonism Relat Disord. 2004 Oct;10(7):407-10. doi: 10.1016/j.parkreldis.2004.04.011.

Abstract

We administered a culturally corrected University of Pennsylvania Smell Identification Test (ccUPSIT) consisting of 25 odor items to 20 patients with 'Lubag' or X-linked dystonia-parkinsonism and 20 control subjects matched by sex, age, educational background, smoking history, and geographical origin. The mean ccUPSIT score of Lubag patients (18 +/- 3.19) was statistically lower (P = 0.003) than controls (20.5 +/- 3.02). The smell scores did not correlate with phenotype, severity of dystonia, or duration of disease. Nine of 20 Lubag patients (45%) had ccUPSIT scores below the mean, with the lowest score being 11. This pilot study suggests that olfactory dysfunction may occur in Lubag patients.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Dystonia / diagnosis*
  • Dystonia / genetics*
  • Genetic Diseases, X-Linked / diagnosis*
  • Genetic Diseases, X-Linked / genetics*
  • Humans
  • Male
  • Middle Aged
  • Odorants
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / genetics*
  • Pilot Projects
  • Smell / genetics*