How do memory systems interact? Evidence from human classification learning

Russell A Poldrack; Paul Rodriguez

doi:10.1016/j.nlm.2004.05.003

How do memory systems interact? Evidence from human classification learning

Neurobiol Learn Mem. 2004 Nov;82(3):324-32. doi: 10.1016/j.nlm.2004.05.003.

Authors

Russell A Poldrack¹, Paul Rodriguez

Affiliation

¹ Department of Psychology and Brain Research Institute, UCLA, Los Angeles, CA 90095, USA. poldrack@ucla.edu

PMID: 15464413
DOI: 10.1016/j.nlm.2004.05.003

Abstract

Studies of human classification learning using functional neuroimaging have suggested that basal ganglia and medial temporal lobe memory systems may interact during learning. We review these results and outline a set of possible mechanisms for such interactions. Effective connectivity analyses suggest that interaction between basal ganglia and medial temporal lobe are mediated by prefrontal cortex rather than by direct connectivity between regions. A review of possible neurobiological mechanisms suggests that interactions may be driven by neuromodulatory systems in addition to mediation by interaction of inputs to prefrontal cortical neurons. These results suggest that memory system interactions may reflect multiple mechanisms that combine to optimize behavior based on experience.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Basal Ganglia / physiology*
Brain Mapping*
Humans
Learning / classification*
Learning / physiology*
Magnetic Resonance Imaging
Memory / classification
Memory / physiology*
Neostriatum / physiology
Prefrontal Cortex / physiology*
Temporal Lobe / physiology*