Abstract
Biological activity of low molecular DNA isolated from salmon milt was studied. When administered subcutaneously to mice with with acute experimental radiation disease in a course dose of 10 mg/kg, it showed a therapeutic effect, stimulated hemopoiesis, increased the survival rate and the average life span of the animals. Moreover, its marked effect on the humoral immunity was observed.
MeSH terms
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Acute Disease
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Animals
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Animals, Outbred Strains
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Antibody Formation / drug effects
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Antibody Formation / radiation effects
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Antibody-Producing Cells / drug effects
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Antibody-Producing Cells / physiology
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Cell Proliferation / drug effects
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DNA / chemistry
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DNA / isolation & purification
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DNA / therapeutic use*
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Hemagglutinins / biosynthesis
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Hematopoiesis / drug effects*
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Hematopoiesis / radiation effects
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Injections, Subcutaneous
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Longevity / drug effects
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Longevity / radiation effects
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred CBA
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Molecular Weight
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Radiation Injuries, Experimental / drug therapy*
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Radiation Injuries, Experimental / immunology
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Radiation Injuries, Experimental / physiopathology
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Spleen / drug effects
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Spleen / radiation effects