[Experimental study on the effect of low molecular DNA from salmon milt on hemopoiesis]

Antibiot Khimioter. 2004;49(4):7-10.
[Article in Russian]

Abstract

Biological activity of low molecular DNA isolated from salmon milt was studied. When administered subcutaneously to mice with with acute experimental radiation disease in a course dose of 10 mg/kg, it showed a therapeutic effect, stimulated hemopoiesis, increased the survival rate and the average life span of the animals. Moreover, its marked effect on the humoral immunity was observed.

Publication types

  • English Abstract

MeSH terms

  • Acute Disease
  • Animals
  • Animals, Outbred Strains
  • Antibody Formation / drug effects
  • Antibody Formation / radiation effects
  • Antibody-Producing Cells / drug effects
  • Antibody-Producing Cells / physiology
  • Cell Proliferation / drug effects
  • DNA / chemistry
  • DNA / isolation & purification
  • DNA / therapeutic use*
  • Hemagglutinins / biosynthesis
  • Hematopoiesis / drug effects*
  • Hematopoiesis / radiation effects
  • Injections, Subcutaneous
  • Longevity / drug effects
  • Longevity / radiation effects
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Molecular Weight
  • Radiation Injuries, Experimental / drug therapy*
  • Radiation Injuries, Experimental / immunology
  • Radiation Injuries, Experimental / physiopathology
  • Spleen / drug effects
  • Spleen / radiation effects

Substances

  • Hemagglutinins
  • DNA