New aspects on the preparation of [11C]acetate--a simple and fast approach via distillation

Markus Mitterhauser; Wolfgang Wadsak; Andreas Krcal; Joern Schmaljohann; Ewald Bartosch; Harald Eidherr; Helmut Viernstein; Kurt Kletter

doi:10.1016/j.apradiso.2004.03.060

New aspects on the preparation of [11C]acetate--a simple and fast approach via distillation

Appl Radiat Isot. 2004 Dec;61(6):1147-50. doi: 10.1016/j.apradiso.2004.03.060.

Authors

Markus Mitterhauser¹, Wolfgang Wadsak, Andreas Krcal, Joern Schmaljohann, Ewald Bartosch, Harald Eidherr, Helmut Viernstein, Kurt Kletter

Affiliation

¹ Department of Nuclear Medicine, University of Vienna, AKH Wien, Waehringer Guertel 18-20, Vienna A1090, Austria. markus.mitterhauser@akh-wien.ac.at

PMID: 15388102
DOI: 10.1016/j.apradiso.2004.03.060

Abstract

[11C]Acetate, initially developed for nuclear cardiology has gained increased interest also for oncological problems. A conjoint problem of all preparation methods is the high sensitivity of the Grignard-precursor to moisture, demanding long cleaning and drying procedures of apparatus and reaction vials. Our rationale was to simplify and accelerate the preparation of [11C]acetate by the development of an inert, sterile and disposable system. The present publication deals with the remote-controlled preparation of [11C]acetate via distillation into a buffer ready to use.

Publication types

Evaluation Study

MeSH terms

Acetates / chemical synthesis*
Acetates / isolation & purification*
Carbon / isolation & purification*
Chemical Fractionation / instrumentation*
Chemical Fractionation / methods*
Equipment Design
Equipment Failure Analysis
Isotope Labeling / instrumentation*
Isotope Labeling / methods*
Positron-Emission Tomography / methods
Radiopharmaceuticals / chemical synthesis
Radiopharmaceuticals / isolation & purification

Substances

Acetates
Radiopharmaceuticals
carbon-11 acetate
Carbon