Screening study for potential lead compounds for natural product-based fungicides: I. Synthesis and in vitro evaluation of coumarins against Botrytis cinerea

Pest Manag Sci. 2004 Sep;60(9):927-32. doi: 10.1002/ps.891.

Abstract

An efficient, one-pot synthesis of angular and linear dihydropyranocoumarins, along with C-6 and C-8 prenylated coumarins is reported. These compounds, together with single- and furanocoumarins, were tested for their potential antifungal activity against the phytopathogen Botrytis cinerea Pers ex Fr. The results show that furanocoumarins may be able to control the fungus B cinerea.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Factors / chemical synthesis
  • Biological Factors / toxicity*
  • Botrytis / drug effects*
  • Coumarins / chemical synthesis
  • Coumarins / toxicity*
  • Culture Techniques
  • Fungicides, Industrial / chemical synthesis
  • Fungicides, Industrial / toxicity*
  • Furocoumarins / chemical synthesis
  • Furocoumarins / toxicity
  • Pest Control, Biological / methods*
  • Protein Prenylation

Substances

  • Biological Factors
  • Coumarins
  • Fungicides, Industrial
  • Furocoumarins