Streptococcus pyogenes and human neutrophils: a paradigm for evasion of innate host defense by bacterial pathogens

Jovanka M Voyich; James M Musser; Frank R DeLeo

doi:10.1016/j.micinf.2004.05.022

Streptococcus pyogenes and human neutrophils: a paradigm for evasion of innate host defense by bacterial pathogens

Microbes Infect. 2004 Oct;6(12):1117-23. doi: 10.1016/j.micinf.2004.05.022.

Authors

Jovanka M Voyich¹, James M Musser, Frank R DeLeo

Affiliation

¹ Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.

PMID: 15380782
DOI: 10.1016/j.micinf.2004.05.022

Abstract

Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms. Although most invading bacteria are eliminated by PMNs, some have evolved complex strategies to prevent normal PMN function. This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms.

Publication types

Review

MeSH terms

Apoptosis
Humans
Immunity, Innate*
Neutrophils / immunology*
Neutrophils / microbiology
Neutrophils / physiology
Phagocytosis
Streptococcal Infections / immunology
Streptococcal Infections / microbiology
Streptococcus pyogenes / pathogenicity*