Age-related changes in the visual cortex: a review

Arch Gerontol Geriatr. 1993 Nov-Dec;17(3):145-64. doi: 10.1016/0167-4943(93)90047-l.

Abstract

The main age related changes in visual cortex are reviewed. The visual cortex (occipital cortex, areas 17-19) undergoes a variety of anatomical, biochemical and functional changes with aging. From a morphological point of view the visual cortex loses nerve cells mainly in the last period of life. From a biochemical point of view cholinergic, serotonergic, and GABAergic neurotransmissions seem to be the most remarkably affected. In terms of functional correlates, a decline of several activities of the visual cortex has been documented in the elderly. Due to the importance of visual cortex in the realization of visual function, the influence of aging on this cerebrocortical area requires a more detailed analysis.