Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4519-23. doi: 10.1016/j.bmcl.2004.06.039.

Abstract

Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Humans
  • Methicillin Resistance / drug effects*
  • Methicillin Resistance / physiology
  • Microbial Sensitivity Tests
  • Naphthoquinones / chemical synthesis*
  • Naphthoquinones / pharmacology*
  • Sesquiterpenes / chemical synthesis*
  • Sesquiterpenes / pharmacology*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / growth & development
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Naphthoquinones
  • Sesquiterpenes
  • mansonone F