DD1.5k, the gene preferentially expressed in bloodstream isolates of vancomycin-resistant Enterococcus faecium

J Microbiol. 2004 Jun;42(2):143-6.

Abstract

Vancomycin-resistant Enterococcus faecium (VREFM) is becoming a threatening pathogen. We identified a gene called DD1.5K by differential display-PCR, which was preferentially expressed in the bloodstream isolates of VREFM. Due to its amino acid similarity to transfer complex protein, trsE, and tissue-specific expression, this gene may be involved in virulence of VREFM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics*
  • Blood / microbiology*
  • Chickens / blood
  • Chickens / microbiology
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / isolation & purification
  • Enterococcus faecium / genetics*
  • Enterococcus faecium / growth & development
  • Enterococcus faecium / isolation & purification
  • Enterococcus faecium / metabolism
  • Gene Expression Profiling / methods
  • Gene Expression Regulation, Bacterial*
  • Genes, Bacterial
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Vancomycin Resistance / genetics
  • Virulence Factors / genetics*

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • Virulence Factors

Associated data

  • GENBANK/AY273800