In vitro cytotoxic activities of 2-alkyl-4,6-diheteroalkyl-1,3,5-triazines: new molecules in anticancer research

Rita Menicagli; Simona Samaritani; Giovanni Signore; Francesca Vaglini; Lisa Dalla Via

doi:10.1021/jm0495374

In vitro cytotoxic activities of 2-alkyl-4,6-diheteroalkyl-1,3,5-triazines: new molecules in anticancer research

J Med Chem. 2004 Sep 9;47(19):4649-52. doi: 10.1021/jm0495374.

Authors

Rita Menicagli, Simona Samaritani, Giovanni Signore, Francesca Vaglini, Lisa Dalla Via

PMID: 15341480
DOI: 10.1021/jm0495374

Abstract

The cytotoxic activities of new 2-alkyl-4,6-dihetero(N,O)alkyl-1,3,5-triazines toward selected tumor cell lines have been evaluated, and for the first time, the potential of 2-alkyl-4,6-dialkoxy-1,3,5-triazines has been shown.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / therapeutic use
Antineoplastic Agents / toxicity*
Biomedical Research
Cell Death / drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Molecular Structure
Neoplasms / drug therapy*
Neoplasms / pathology*
Structure-Activity Relationship

Substances

Antineoplastic Agents