Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy

Rheumatol Int. 2005 May;25(4):311-3. doi: 10.1007/s00296-004-0502-9. Epub 2004 Aug 25.

Abstract

Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (total dose 1702.5 mg). This may be the first such case reported in the literature.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / pathology
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Folic Acid / therapeutic use
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Leukemia, Erythroblastic, Acute / etiology*
  • Leukemia, Erythroblastic, Acute / pathology
  • Methotrexate / therapeutic use*
  • Treatment Outcome

Substances

  • Antirheumatic Agents
  • Hydroxychloroquine
  • Folic Acid
  • Methotrexate