Penasulfate A, a new alpha-glucosidase inhibitor from a marine sponge Penares sp

J Nat Prod. 2004 Aug;67(8):1346-50. doi: 10.1021/np049939e.

Abstract

A new alpha-glucosidase inhibitor, penasulfate A, has been isolated from a marine sponge Penares sp.(1) Its structure was elucidated by spectral and chemical methods to be a scalemic mixture of methyl pipecolates acylated with a novel sulfated fatty acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Fatty Acids / chemistry
  • Fatty Acids / isolation & purification*
  • Fatty Acids / pharmacology
  • Glycoside Hydrolase Inhibitors*
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / isolation & purification*
  • Hypoglycemic Agents / pharmacology
  • Japan
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Pipecolic Acids / chemistry
  • Pipecolic Acids / isolation & purification*
  • Pipecolic Acids / pharmacology
  • Porifera / chemistry*

Substances

  • Enzyme Inhibitors
  • Fatty Acids
  • Glycoside Hydrolase Inhibitors
  • Hypoglycemic Agents
  • Pipecolic Acids
  • penasulfate A