Abstract
A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Animals
-
Antineoplastic Agents
-
Drug Screening Assays, Antitumor
-
Hawaii
-
Inhibitory Concentration 50
-
Leukemia P388
-
Mice
-
Molecular Conformation
-
Molecular Structure
-
Mollusca
-
Peptides, Cyclic / chemistry
-
Peptides, Cyclic / isolation & purification*
-
Peptides, Cyclic / pharmacology
-
Stereoisomerism
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Peptides, Cyclic
-
kulokekahilide-2