Magnetoresistive-based biosensors and biochips

Trends Biotechnol. 2004 Sep;22(9):455-62. doi: 10.1016/j.tibtech.2004.06.006.

Abstract

Over the past five years, magnetoelectronics has emerged as a promising new platform technology for biosensor and biochip development. The techniques are based on the detection of the magnetic fringe field of a magnetically labeled biomolecule interacting with a complementary biomolecule bound to a magnetic-field sensor. Magnetoresistive-based sensors, conventionally used as read heads in hard disk drives, have been used in combination with biologically functionalized magnetic labels to demonstrate the detection of molecular recognition. Real-world bio-applications are now being investigated, enabling tailored device design, based on sensor and label characteristics. This detection platform provides a robust, inexpensive sensing technique with high sensitivity and considerable scope for quantitative signal data, enabling magnetoresistive biochips to meet specific diagnostic needs that are not met by existing technologies.

Publication types

  • Review

MeSH terms

  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • Biosensing Techniques / trends
  • Biotin / chemistry
  • DNA Probes / chemistry
  • DNA Probes / genetics
  • Electric Impedance
  • Ferric Compounds / chemistry
  • Lab-On-A-Chip Devices
  • Magnetics*
  • Microchip Analytical Procedures / methods*
  • Microspheres
  • Nanostructures / chemistry
  • Nanotechnology
  • Nucleic Acid Hybridization / methods
  • Streptavidin / chemistry

Substances

  • DNA Probes
  • Ferric Compounds
  • ferric oxide
  • Biotin
  • Streptavidin