Abstract
The pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amphotericin B / administration & dosage
-
Amphotericin B / analogs & derivatives
-
Amphotericin B / pharmacokinetics*
-
Amphotericin B / therapeutic use*
-
Animals
-
Antifungal Agents / administration & dosage
-
Antifungal Agents / pharmacokinetics*
-
Antifungal Agents / therapeutic use*
-
Area Under Curve
-
Aspergillosis / drug therapy*
-
Aspergillosis / microbiology
-
Aspergillus fumigatus
-
Chemistry, Pharmaceutical
-
Chromatography, High Pressure Liquid
-
Colony Count, Microbial
-
Galactans / administration & dosage
-
Galactans / pharmacokinetics*
-
Galactans / therapeutic use*
-
Half-Life
-
Kidney / microbiology
-
Liver / microbiology
-
Lung / microbiology
-
Male
-
Mice
-
Mice, Inbred BALB C
-
Tissue Distribution
Substances
-
Antifungal Agents
-
Galactans
-
amphotericin B-arabinogalactan conjugate
-
Amphotericin B