Emergence of macrolide-resistant Streptococcus pyogenes strains in French children

Antimicrob Agents Chemother. 2004 Sep;48(9):3559-62. doi: 10.1128/AAC.48.9.3559-3562.2004.

Abstract

We studied the antimicrobial susceptibility of 322 Streptococcus pyogenes throat isolates from French children and their serotype and genomic diversity. A total of 22.4% were erythromycin resistant, and 69.4, 4.2, and 26.4% of these isolates harbored ermB, ermA, and mefA, respectively. Increasing resistance in France is mainly associated with a few emm type 28 clones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Child
  • Child, Preschool
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • France / epidemiology
  • Genome, Bacterial
  • Humans
  • Macrolides / pharmacology*
  • Membrane Proteins / genetics
  • Methyltransferases / genetics
  • Microbial Sensitivity Tests
  • Pharyngitis / microbiology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Serotyping
  • Streptococcal Infections / epidemiology*
  • Streptococcal Infections / microbiology*
  • Streptococcus pyogenes / drug effects*
  • Streptococcus pyogenes / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • Macrolides
  • MefA protein, Streptococcus
  • Membrane Proteins
  • Methyltransferases
  • ErmA protein, Bacteria