Abstract
We studied the antimicrobial susceptibility of 322 Streptococcus pyogenes throat isolates from French children and their serotype and genomic diversity. A total of 22.4% were erythromycin resistant, and 69.4, 4.2, and 26.4% of these isolates harbored ermB, ermA, and mefA, respectively. Increasing resistance in France is mainly associated with a few emm type 28 clones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Child
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Child, Preschool
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial
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Electrophoresis, Gel, Pulsed-Field
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France / epidemiology
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Genome, Bacterial
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Humans
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Macrolides / pharmacology*
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Membrane Proteins / genetics
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Methyltransferases / genetics
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Microbial Sensitivity Tests
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Pharyngitis / microbiology
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Reverse Transcriptase Polymerase Chain Reaction
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Serotyping
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Streptococcal Infections / epidemiology*
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Streptococcal Infections / microbiology*
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Streptococcus pyogenes / drug effects*
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Streptococcus pyogenes / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA, Bacterial
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Macrolides
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MefA protein, Streptococcus
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Membrane Proteins
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Methyltransferases
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ErmA protein, Bacteria