Arginine methylation regulates the cytokine response

François-Michel Boisvert; Stéphane Richard

doi:10.1016/j.molcel.2004.08.011

Arginine methylation regulates the cytokine response

Mol Cell. 2004 Aug 27;15(4):492-4. doi: 10.1016/j.molcel.2004.08.011.

Authors

François-Michel Boisvert¹, Stéphane Richard

Affiliation

¹ Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Departments of Oncology and Medicine, McGill University, Montréal, Québec, Canada H3T 1E2.

PMID: 15327764
DOI: 10.1016/j.molcel.2004.08.011

Abstract

The recent identification of the NFAT-interacting protein NIP45 as a methylated protein by marks a new role for protein arginine methylation in lymphocyte signaling and cytokine gene activation.

Publication types

Comment

MeSH terms

Arginine / metabolism*
Carrier Proteins / metabolism
Cytokines / immunology
Cytokines / metabolism*
DNA-Binding Proteins / metabolism
Gene Expression Regulation*
Intracellular Signaling Peptides and Proteins*
Methylation
NFATC Transcription Factors
Nuclear Proteins / metabolism
Protein-Arginine N-Methyltransferases / metabolism
Signal Transduction / physiology
T-Lymphocytes / immunology
T-Lymphocytes / metabolism
Transcription Factors / metabolism
Transcriptional Activation

Substances

Carrier Proteins
Cytokines
DNA-Binding Proteins
Intracellular Signaling Peptides and Proteins
NFATC Transcription Factors
Nfatc2ip protein, mouse
Nuclear Proteins
Transcription Factors
Arginine
Protein-Arginine N-Methyltransferases