Effects of edaravone on reperfusion injury in patients with acute myocardial infarction

Am J Cardiol. 2004 Aug 15;94(4):481-4. doi: 10.1016/j.amjcard.2004.05.007.

Abstract

This clinical pilot study was a randomized, controlled, open-label study in 80 patients with acute myocardial infarction and was designed to examine the effects of a novel free radical scavenger, edaravone. Administration of edaravone before myocardial reperfusion was associated with smaller enzymatic infarcts and better clinical outcome.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary*
  • Antipyrine / adverse effects
  • Antipyrine / analogs & derivatives*
  • Antipyrine / therapeutic use*
  • Creatine Kinase / blood
  • Creatine Kinase, MB Form
  • Edaravone
  • Female
  • Free Radical Scavengers / adverse effects
  • Free Radical Scavengers / therapeutic use*
  • Humans
  • Isoenzymes / blood
  • Male
  • Middle Aged
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / drug therapy*
  • Myocardial Reperfusion Injury / diagnosis
  • Myocardial Reperfusion Injury / prevention & control*
  • Pilot Projects
  • Stents*
  • Thrombolytic Therapy*
  • Treatment Outcome

Substances

  • Free Radical Scavengers
  • Isoenzymes
  • Creatine Kinase
  • Creatine Kinase, MB Form
  • Edaravone
  • Antipyrine