Rodent models for the study of therapy against flavivirus infections

Nathalie Charlier; Pieter Leyssen; Erik De Clercq; Johan Neyts

doi:10.1016/j.antiviral.2004.06.007

Rodent models for the study of therapy against flavivirus infections

Antiviral Res. 2004 Aug;63(2):67-77. doi: 10.1016/j.antiviral.2004.06.007.

Authors

Nathalie Charlier¹, Pieter Leyssen, Erik De Clercq, Johan Neyts

Affiliation

¹ Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

PMID: 15321702
DOI: 10.1016/j.antiviral.2004.06.007

Abstract

Flaviviruses cause a variety of diseases including (meningo)encephalitis and hemorrhagic fevers. There is no specific antiviral therapy available for the treatment of infections with flaviviruses and such therapy should be urgently developed. Small animal models that are reminiscent of the disease in man will be instrumental to identify therapeutic strategies against flavivirus infections. Here we review models in mice and hamsters that may be used to assess the efficacy of novel antiviral strategies against flavivirus infections.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antiviral Agents / therapeutic use*
Cricetinae
Disease Models, Animal*
Drug Evaluation, Preclinical*
Flavivirus / drug effects*
Flavivirus / pathogenicity
Flavivirus Infections / drug therapy*
Hemorrhagic Fevers, Viral / drug therapy
Hemorrhagic Fevers, Viral / virology
Meningoencephalitis / drug therapy
Meningoencephalitis / virology
Mice

Substances

Antiviral Agents