Homologous recombination: down to the wire

Curr Biol. 2004 Aug 10;14(15):R629-31. doi: 10.1016/j.cub.2004.07.049.

Abstract

Exchange of strands between homologous DNA molecules is catalyzed by evolutionarily conserved recombinases. These proteins can occur in different quaternary arrangements: rings or helical filaments. Recent results reveal that recombinase function follows from the filamentous form.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Cell Cycle Proteins / metabolism
  • DNA / chemistry
  • DNA / metabolism*
  • DNA-Binding Proteins / metabolism
  • Models, Chemical*
  • Protein Conformation
  • Rec A Recombinases / chemistry
  • Rec A Recombinases / metabolism*
  • Recombination, Genetic*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Adenosine Triphosphate
  • DNA
  • Rec A Recombinases