Abstract
Physical inactivity-gene interactions result in changes in gene expression, leading to phenotypic changes in the skeletal muscle cell. A subpopulation of those genes that show changes in expression during physical inactivity are candidates for the environment-gene interactions that cross a threshold of biological significance such that overt clinical disease occurs. AMP kinase, GLUT4 and myosin heavy chain IIx are proposed as candidates for physical inactivity-modulated genes that have an altered function that may trigger a crossing of a threshold to disease. Future experiments will be needed to test the validity of the ideas presented.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenylate Kinase / genetics
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Adenylate Kinase / physiology
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Environment
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Exercise / physiology*
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Gene Expression
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Glucose Transporter Type 4
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Humans
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Life Style
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Monosaccharide Transport Proteins / genetics
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Monosaccharide Transport Proteins / physiology
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Muscle Proteins / genetics
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Muscle Proteins / physiology
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Muscle, Skeletal / cytology
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Muscle, Skeletal / physiology*
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Myosin Heavy Chains / genetics
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Myosin Heavy Chains / physiology
Substances
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Glucose Transporter Type 4
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Monosaccharide Transport Proteins
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Muscle Proteins
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SLC2A4 protein, human
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Adenylate Kinase
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Myosin Heavy Chains