Chipping away at 'stemness'

Genome Biol. 2004;5(8):235. doi: 10.1186/gb-2004-5-8-235. Epub 2004 Jul 29.

Abstract

Global gene-expression analyses of human embryonic stem cells confirm the involvement of some known genes in stem-cell function and identify some new candidate regulators of stem-cell growth. Support remains elusive, however, for the concept of 'stemness'--a pattern of expression of genes that is common to all stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Differentiation / genetics*
  • Embryo, Mammalian / cytology*
  • Embryo, Mammalian / metabolism*
  • Gene Expression Profiling*
  • Genomics
  • Humans
  • Stem Cells / cytology*
  • Stem Cells / metabolism*
  • Transcription, Genetic / genetics*