Abstract
(+)-Dehydrovomifoliol (1), 3-hydroxy-5alpha,6alpha-epoxy-beta-ionone (2), vitexin 7-O-beta-D-glucopyranoside (3), and vitexin 2''-O-beta-D-glucopyranoside (4) were isolated as new constituents from the aerial parts of Beta vulgaris var. cicla. Compounds 3 and 4 demonstrated hepatoprotective activity with values of 65.8 and 56.1%, respectively, in primary cultured rat hepatocytes with CCl4-induced cell toxicity, compared to controls. This was comparable to that of silibinin (69.8 %) which was used as a positive control.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Beta vulgaris / chemistry*
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Carbon Tetrachloride / toxicity
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Cells, Cultured
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Flavones / chemistry
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Flavones / isolation & purification
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Flavones / pharmacology*
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Hepatocytes / drug effects*
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Male
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Norisoprenoids / chemistry
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Norisoprenoids / isolation & purification
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Norisoprenoids / pharmacology*
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Plant Components, Aerial / chemistry*
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Plant Extracts / chemistry
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Protective Agents / chemistry
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Protective Agents / isolation & purification
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Protective Agents / pharmacology*
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Rats
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Rats, Wistar
Substances
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Flavones
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Glycosides
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Norisoprenoids
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Plant Extracts
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Protective Agents
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Carbon Tetrachloride