Alternative splicing of murine interleukin-4 mRNA

O P Yatsenko; M L Filipenko; E N Voronina; E A Khrapov; S V Sennikov; V A Kozlov

doi:10.1023/b:bebm.0000028134.41152.fb

Alternative splicing of murine interleukin-4 mRNA

Bull Exp Biol Med. 2004 Feb;137(2):179-81. doi: 10.1023/b:bebm.0000028134.41152.fb.

[Article in English, Russian]

Authors

O P Yatsenko¹, M L Filipenko, E N Voronina, E A Khrapov, S V Sennikov, V A Kozlov

Affiliation

¹ Laboratory of Immunopoesis Regulation, Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.

PMID: 15273769
DOI: 10.1023/b:bebm.0000028134.41152.fb

Abstract

We found an alternative form of mRNA with spliced second exon (IL-4delta2 mRNA) in mouse bone marrow and splenic cells. At rest, the amount of IL-4 mRNA markedly surpassed that of IL-4delta2 mRNA. Stimulation increased the content of both mRNA forms, but the alternative variant is accumulated more intensively and rapidly. We did not detect predominance of IL-4delta2 mRNA over full-length mRNA variant in the studied mouse tissues.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alternative Splicing*
Animals
Base Sequence
Bone Marrow Cells / immunology
DNA Primers / genetics
DNA, Complementary / genetics
Exons
In Vitro Techniques
Interleukin-4 / genetics*
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
RNA, Messenger / genetics*
RNA, Messenger / metabolism*
Spleen / cytology
Spleen / immunology
Tissue Distribution

Substances

DNA Primers
DNA, Complementary
RNA, Messenger
Interleukin-4