Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice
Bull Exp Biol Med. 2004 Feb;137(2):111-3.
doi: 10.1023/b:bebm.0000028115.53995.e0.
[Article in
English,
Russian]
Affiliation
- 1 Laboratory of Biological Assays, Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia. lobanov_al@pisem.net
Abstract
We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginine in NMRI mice. Atropine reduced, while hexamethonium completely abolished the arrhythmogenic effect of endothelin-1 during nitric oxide synthase inhibition. Atenolol potentiated arrhythmogenic activity of Nomega-nitro-L-arginine, but endothelin-1 had no effect on the incidence of arrhythmias under these conditions.
MeSH terms
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Adrenergic Antagonists / pharmacology*
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Animals
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Arrhythmias, Cardiac / chemically induced
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Arrhythmias, Cardiac / metabolism
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Arrhythmias, Cardiac / prevention & control*
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Atenolol / pharmacology
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Atropine / pharmacology
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Cholinergic Antagonists / pharmacology*
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Endothelin-1 / pharmacology
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Hexamethonium / pharmacology
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Male
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Mice
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NG-Nitroarginine Methyl Ester / pharmacology
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Nitric Oxide / biosynthesis
Substances
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Adrenergic Antagonists
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Cholinergic Antagonists
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Endothelin-1
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Nitric Oxide
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Hexamethonium
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Atenolol
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Atropine
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NG-Nitroarginine Methyl Ester