Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2=salicylic acid)

J Inorg Biochem. 2004 Aug;98(8):1361-6. doi: 10.1016/j.jinorgbio.2004.04.016.

Abstract

[Ag(2)(NH(3))(2)(salH)(2)] (salH(2)=salicylic acid) was synthesised from salicylic acid and Ag(2)O in concentrated aqueous NH(3) and the dimeric Ag(I) complex was characterised using X-ray crystallography. The complex is centrosymmetric with each metal coordinated to a salicylate carboxylate oxygen and to an ammonia nitrogen atom in an almost linear fashion. The two [Ag(NH(3))(salH)] units in the complex are linked by an Ag-Ag bond. Whilst metal-free salH(2) did not prevent the growth of the fungal pathogen Candida albicans [Ag(2)(NH(3))(2)(salH)(2)], [Ag(2)(salH)(2)] and some simple Ag(I) salts greatly inhibited cell reproduction. SalH(2), [Ag(2)(NH(3))(2)(salH)(2)] [Ag(2)(salH)(2)] and AgClO(4) produced a dose-dependent cytotoxic response against the three human derived cancer cell lines, Cal-27, Hep-G2 and A-498, with the Ag(I)-containing reagents being the most effective.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antifungal Agents* / chemistry
  • Antifungal Agents* / therapeutic use
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / therapeutic use
  • Candida albicans / metabolism
  • Candidiasis / drug therapy
  • Cell Line, Tumor
  • Crystallography, X-Ray
  • Humans
  • Molecular Structure
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / therapeutic use
  • Salicylic Acid* / chemistry
  • Salicylic Acid* / therapeutic use
  • Silver Compounds* / chemistry
  • Silver Compounds* / therapeutic use

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Organometallic Compounds
  • Silver Compounds
  • Salicylic Acid