TCR signaling: another Abl-bodied kinase joins the cascade

Curr Biol. 2004 Jul 27;14(14):R562-4. doi: 10.1016/j.cub.2004.07.012.

Abstract

Protein tyrosine kinases have long been recognized as the most proximal actors in T-cell antigen receptor (TCR) signaling. Three non-receptor tyrosine kinase families (Src, ZAP-70 and Tec) are known to be critical, but a new study now shows that room needs to be made in this pathway for yet another protein tyrosine kinase family - Abl/Arg.

Publication types

  • Comment
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Benzamides
  • Carrier Proteins / metabolism
  • Gene Expression Regulation*
  • Humans
  • Imatinib Mesylate
  • Lymphocyte Activation / physiology*
  • Membrane Proteins / metabolism
  • Phosphoproteins / metabolism
  • Piperazines / metabolism
  • Protein Structure, Tertiary
  • Protein-Tyrosine Kinases / metabolism*
  • Pyrimidines / metabolism
  • Receptors, Antigen, T-Cell / metabolism*
  • Signal Transduction / physiology*
  • ZAP-70 Protein-Tyrosine Kinase

Substances

  • Adaptor Proteins, Signal Transducing
  • Benzamides
  • Carrier Proteins
  • LAT protein, human
  • Membrane Proteins
  • Phosphoproteins
  • Piperazines
  • Pyrimidines
  • Receptors, Antigen, T-Cell
  • SLP-76 signal Transducing adaptor proteins
  • Imatinib Mesylate
  • ARG tyrosine kinase
  • Protein-Tyrosine Kinases
  • ZAP-70 Protein-Tyrosine Kinase
  • ZAP70 protein, human