Abstract
Protein tyrosine kinases have long been recognized as the most proximal actors in T-cell antigen receptor (TCR) signaling. Three non-receptor tyrosine kinase families (Src, ZAP-70 and Tec) are known to be critical, but a new study now shows that room needs to be made in this pathway for yet another protein tyrosine kinase family - Abl/Arg.
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Benzamides
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Carrier Proteins / metabolism
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Gene Expression Regulation*
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Humans
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Imatinib Mesylate
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Lymphocyte Activation / physiology*
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Membrane Proteins / metabolism
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Phosphoproteins / metabolism
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Piperazines / metabolism
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Protein Structure, Tertiary
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Protein-Tyrosine Kinases / metabolism*
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Pyrimidines / metabolism
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Receptors, Antigen, T-Cell / metabolism*
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Signal Transduction / physiology*
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ZAP-70 Protein-Tyrosine Kinase
Substances
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Adaptor Proteins, Signal Transducing
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Benzamides
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Carrier Proteins
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LAT protein, human
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Membrane Proteins
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Phosphoproteins
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Piperazines
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Pyrimidines
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Receptors, Antigen, T-Cell
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SLP-76 signal Transducing adaptor proteins
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Imatinib Mesylate
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ARG tyrosine kinase
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Protein-Tyrosine Kinases
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ZAP-70 Protein-Tyrosine Kinase
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ZAP70 protein, human