New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization

Chem Commun (Camb). 2004 Jul 21:(14):1624-5. doi: 10.1039/b402760d. Epub 2004 Jun 15.

Abstract

The functionalization of an oligonucleotide by flavin and deazaflavin derivatives allowed an amperometric determination of the hybridization process through the disappearance of the electroactivity of the free oligonucleotide and the appearance of a new electrochemical signal characteristic of the resulting duplex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Biosensing Techniques
  • DNA / analysis
  • DNA Probes*
  • Electrochemistry / methods*
  • Flavins / chemistry*
  • Molecular Structure
  • Oligodeoxyribonucleotides / chemistry*

Substances

  • DNA Probes
  • Flavins
  • Oligodeoxyribonucleotides
  • DNA