Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells

Diana Ivanova; Aurélie Rossin; Hinrich Gronemeyer; Alain Valla; Dominique Cartier; Régis Le Guillou; Roger Labia

doi:10.1016/j.bmcl.2004.06.002

Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4257-61. doi: 10.1016/j.bmcl.2004.06.002.

Authors

Diana Ivanova¹, Aurélie Rossin, Hinrich Gronemeyer, Alain Valla, Dominique Cartier, Régis Le Guillou, Roger Labia

Affiliation

¹ Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France.

PMID: 15261282
DOI: 10.1016/j.bmcl.2004.06.002

Abstract

New structure-activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Death
Cell Differentiation
Cell Line, Tumor
Humans
Hydrocarbons
Leukemia, Promyelocytic, Acute / pathology*
Methane / analogs & derivatives*
Methane / chemistry*
Methane / pharmacology*
Retinoids / chemistry*
Retinoids / pharmacology*
Structure-Activity Relationship

Substances

Hydrocarbons
Retinoids
carbene
Methane