Progestin-induced fatty acid synthetase in human mammary tumors: from molecular to clinical studies

D Chalbos; C Joyeux; F Galtier; H Rochefort

doi:10.1016/0960-0760(92)90211-z

Progestin-induced fatty acid synthetase in human mammary tumors: from molecular to clinical studies

J Steroid Biochem Mol Biol. 1992 Sep;43(1-3):223-8. doi: 10.1016/0960-0760(92)90211-z.

Authors

D Chalbos¹, C Joyeux, F Galtier, H Rochefort

Affiliation

¹ Unité INSERM 148 Hormones and Cancer, Montpellier, France.

PMID: 1525062
DOI: 10.1016/0960-0760(92)90211-z

Abstract

Fatty acid synthetase (FAS) is one of the first well-characterized progestin-induced proteins with available antibodies and cDNA. This paper reviews basic studies on FAS regulation in human breast cancer cell lines and recent data on the possible clinical significance of this new marker of hormone responsiveness in mammary cancer and benign breast diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Breast Neoplasms / enzymology*
Enzyme Induction
Fatty Acid Synthases / genetics
Fatty Acid Synthases / metabolism*
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Progestins / pharmacology*
Progestins / physiology
Receptors, Progesterone / metabolism

Substances

Biomarkers, Tumor
Progestins
Receptors, Progesterone
Fatty Acid Synthases