Clinicians have been the primary focus of health care worker training in response to the 2001 terrorist and anthrax attacks. However, many nonclinical hospital workers also are critical in providing medical care during any large-scale emergency. We designed a training program, guided by focus groups, to provide them with information to recognize unusual events and to protect themselves. We compared four different training methods: workbook, video, lecture, and a small-group discussion. One hundred and ninety-one workers participated. After the training, they were more confident in their employer's preparedness to respond to a terrorist attack but specific knowledge did not change substantially. Fortunately, the self-directed workbook (the more economical and least disruptive method) was as effective as the other methods. Our experience may be useful to others who are planning terrorism-preparedness training programs.