Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity

Maria T Cocco; Cenzo Congiu; Valentina Onnis; Micaela Morelli; Vicente Felipo; Omar Cauli

doi:10.1016/j.bmc.2004.05.025

Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity

Bioorg Med Chem. 2004 Aug 1;12(15):4169-77. doi: 10.1016/j.bmc.2004.05.025.

Authors

Maria T Cocco¹, Cenzo Congiu, Valentina Onnis, Micaela Morelli, Vicente Felipo, Omar Cauli

Affiliation

¹ Dipartimento di Tossicologia, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy. tcocco@unica.it

PMID: 15246093
DOI: 10.1016/j.bmc.2004.05.025

Abstract

A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.

MeSH terms

Analgesics / chemical synthesis*
Analgesics / pharmacology*
Animals
Carboxylic Acids / chemical synthesis
Carboxylic Acids / pharmacology
Drug Evaluation, Preclinical
Male
Molecular Structure
Motor Activity / drug effects
Motor Activity / physiology
Nicotinic Acids / chemical synthesis*
Nicotinic Acids / pharmacology*
Pain Measurement / drug effects*
Pyridines / chemistry
Rats
Rats, Sprague-Dawley

Substances

Analgesics
Carboxylic Acids
Nicotinic Acids
Pyridines
trifluoromethylpyridine